Major Discoveries

The discovery that chemokines also direct the linage development of T cells

  1. Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N. CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6086-91. PubMed PMID: 28533380. Pubmed Central PMCID: 5468670.
  2. Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N. CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis. J Clin Invest. 2014 May 1;124(5):2009-22. PubMed PMID: 24713654. Pubmed Central PMCID: 4001543.
  3. Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N. CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells. J Exp Med. 2008 Oct 27;205(11):2643-55. PubMed PMID: 18852294. Pubmed Central PMCID: 2571938.
  4. Wildbaum G, Netzer N, Karin N. Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. J Immunol. 2002 Jun 1;168(11):5885-92. PubMed PMID: 12023393. Epub 2002/05/23. eng.
  5. Salomon I, Netzer N, Wildbaum G, Schif-Zuck S, Maor G, Karin N. Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis. J Immunol. 2002 Sep 1;169(5):2685-93. PubMed PMID: 12193742.

The discovery of a novel regulatory mechanism in which autoantibodies to inflammatory cytokines and chemokines restrain autoimmunity

  1. Wildbaum G, Nahir MA, Karin N. Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity. Immunity. 2003 Nov;19(5):679-88. PubMed PMID: 14614855.

    The discovery of adhesion molecule that direct the migration of effector T cells to the inflamed central nervous system- A Nature paper that directly led to the development of the first FDA approved biological drug for Multiple Sclerosis (Tysabri)

    1. Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature. 1992 Mar 5;356(6364):63-6. PubMed PMID: 1538783.




Karin Publications at PubMed Karin Publications at PubMed
Technion - Israel Institute of Technology Technion – Israel Institute of Technology