Chemokines and autoimmunity

A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis.

Sapir, Y., Vitenshtein, A., Barsheshet, Y., Zohar, Y., Wildbaum, G. & Karin, N.J Immunol 185, 2589-2599 (2010).
This manuscript investigates the role of CCR5 ligands in autoimmunity.

Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis.

Wildbaum, G., Netzer, N. & Karin, N.J Immunol 168, 5885-5892 (2002).
This manuscript shows for the first time that a chemokine (CXCL10) may drive the polarization of inflammatory T cells in a model of Multiple Sclerosis.

Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis.

Salomon, I., Netzer, N., Wildbaum, G., Schif-Zuck, S., Maor, G. & Karin, N.J Immunol 169, 2685-2693 (2002).
This manuscript shows the role of CXCL10 in the pathogenesis of rheumatoid arthritis.

C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis.

Youssef, S., Maor, G., Wildbaum, G., Grabie, N., Gour-Lavie, A. & Karin, N.J Clin Invest 106, 361-371 (2000).
This manuscript uses the DNA vaccination technology to explore the role of chemokines in autoimmunity.